Location: Hyatt Regency Cambridge, Cambridge, Massachusetts

Non-coding RNAs have recently been recognized as gene-specific regulators and thus are similar in activity to a large number of protein transcription factors that are known to be critical in the transformation of cells to a malignant state. These RNAs can regulate every stage of gene expression: transcription, mRNA stability, and mRNA translation. Cancer cells have genetic and epigenetic changes from their normal counterparts and the role of non-coding RNAs in mediating these differences is beginning to emerge. These changes are a major focus of this conference. In addition, the use of short RNAs to identify novel cancer-relevant genes and to possibly treat cancer will be discussed.

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